Sophomore guard Soutiri Sapnas scored a game high 35 points to spark the Saints past Cuyahoga Community College.
Sapnas shot 9-for-19 from the field and didn't miss a free throw in 12 attempts.
Damon Jones scored 13 points while Je'Land Head scored 11 to go along with his five assists. Devonte Isom and Quamir White both added 10 points each.
Mercyhurst gave a good defense effort in the first half, holding the Challengers to just 36 percent shooting. That changed in the second half but the Saints took care of the ball, committing just 10 turnovers in the game.
Mercyhurst will be back in action Tuesday when they host Lakeland Community College at 7:30 at Liguori Fieldhouse.